Sanzyme Ltd., was formed on the 5th August 1969 as Unl-Sankyo limited, the first ever Indo-Japanese joint venture with Sankyo Company limited (now known as Daiichi Sankyo, Japan) to manufacture enzymes and gonadotropins with the technology transferred from Sankyo & export to parent company. Thus lead the way as a pioneer in gonadotropins and probiotics in India.
hCG [Human Chorionic
Gonadotropin] obtained from natural sources is aptly termed as the
surrogate LH [Lutenising Hormone] for triggering of
ovulation and maintenance of pregnancy.
Human chorionic
gonadotropin (HCG), a polypeptide hormone produced by the human
placenta, is composed of an alpha and a beta sub-unit. The alpha
sub-unit is essentially identical to the alpha subunits of the human
pituitary gonadotropins, luteinizing hormone (LH) and
follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of
human thyroid-stimulating hormone (TSH). The beta subunits of these
hormones differ in amino acid sequence.
hCG, produced by
specialized cells known as syncytiotrophoblast cells or more
specifically villous syncytiotrophoblast cells as pregnancy progresses .
This is the molecules that promotes progesterone production and other
important biological functions during the course of pregnancy. Today,
the function of hCG is still marked as being progesterone promotion in
most medical student text books, but we now know now that hCG has
numerous other important placental, uterine and fetal functions in
pregnancy. From the time of implantation, hCG produced by trophoblast
cells take over corpus luteal progesterone production from luteinizing
hormone (LH), acting on a joint hCG/LH receptor. This continues for
approximately 3 to 4 weeks. After that time, there are sufficient
syncytiotrophoblast cells in the placenta to take over progesterone
production from corpus luteal cells.
Currently hCG is used for
triggering of ovulation, maintenance of high risk pregnancies and as an
effective agent for preterm labour. Depending on the clinical needs,
dosages ranging from 5000 to 10000 IU of hCG have been used for
triggering ovulation, while the dosage form of 7500 IU has been
exclusively used for women with higher BMI.
Lower doses of hCG
500 IU to 2000 IU, are being used for treating male infertility
disorders ranging from hypogonadotropic hypogonadism , stimulating
endogenous testosterone production.
PUBERGEN [Human
Chorionic Gonadotropin]
- 500 [ [Highly Purified Human
Chorionic Gonadotropin]
- 1000/2000/5000
- 7500 [Highly Purified
Human Chorionic Gonadotropin] and
- 10000 IU
Endogen, belongs to a group known as
urofollitropin and is a product containing a highly purified preparation
of human follicle stimulating hormone (hFSH) extracted from natural
sources. Human FSH consists of two non-covalently linked glycoproteins
designated as the α - and β - subunits. The α subunit has 92 amino acids
of which two are modified by attachment of carbohydrates. The β- subunit
has 111 amino acids of which two are modified by attachment of
carbohydrates.
Endogen (urofollitropin injection) is a sterile,
lyophilized powder intended for subcutaneous (SC) or intramuscular (IM)
injection after reconstitution with sterile 0.9%
Ovulation Induction
Endogen injection is administered SC /
IM , is indicated for ovulation induction in infertile patients who have
previously received agonists or antagonists for pituitary suppression.
Multifollicular Development during ART
Endogen
injection is administered SC/IM is used controlled ovarian stimulation
during ART cycles in patients who have previously received who have
previously received agonists or antagonists for pituitary suppression.
Endogen administered for 7 to 12 days produces ovarian follicular
growth in women who do not have primary ovarian failure. Treatment with
Endogen in most instances results only in follicular growth and
maturation. When sufficient follicular maturation has occurred, hCG must
be given to induce ovulation.
Spermatogenesis in Males
Endogen administered SC/IM is used to stimulate spermatogenesis in males
along with human chorionic gonadotropin
ENDOGEN [Highly
Purified Follicle Stimulating Hormone]
- 75 IU
- 150 IU
Gynogen belongs to a group known as Menotropins
and is a preparation of gonadotropins, extracted from natural sources ,
which has undergone additional steps for purification. Each vial of
Gynogen contains 75 International Units (IU) of follicle-stimulating
hormone (FSH) activity and 75 IU of luteinizing hormone (LH) activity
and 150 International Units (IU) of follicle-stimulating hormone (FSH)
activity and 150 IU of luteinizing hormone (LH) activity.Both FSH and LH
are glycoproteins that are water soluble.
Follicular
Development
Gynogen is administered for 7 to 20 days,
produces ovarian follicular growth and maturation in women who do not
have primary ovarian failure. In order to produce final follicular
maturation and ovulation in the absence of an endogenous LH surge, hCG
must be administered following Gynogen treatment, at a time when patient
monitoring indicates sufficient follicular development has occurred.
Once adequate follicular development is evident, hCG should be
administered to induce final follicular maturation in preparation for
oocyte retrieval.
Spermatogenesis in Males
In males for improving sperm count, with no primary hypogonadism,
Gynogen administered alone or in low doses in conjunction with low doses
of human chorionic gonadotropin, have shown improvement in sperm counts
of males treated.
GYNOGEN [Highly Purified
Menotropin]
- 75 IU [75IU FSH+75 IU LH]
- 150
IU [150 IU FSH+150 IU LH]
All the gonadotropins,
hCG,FSH and HMG are manufactured using a specialized proprietary
trademarked process known as “LYGOTECH”.This process involves using the
right temperature, pressure and removal of water content from the
formulation to ensure:
1. The protein/s that are present in the
formulation are not denatured during manufacturing process
2. Excess
moisture content is removed to ensure the cake formed during
manufactured is easily soluble during reconstitution with diluent
provided and
3. The potency or the strength mentioned on the label is
maintained till the end of the shelf-life